Monoclonal Antibody 11E10, Which Neutralizes Shiga Toxin Type 2 (Stx2), Recognizes Three Regions on the Stx2 A Subunit, Blocks the Enzymatic Action of the Toxin In Vitro, and Alters the Overall Cellular Distribution of the Toxin

Monoclonal antibody (MAb) 11E10 recognizes the Shiga toxin type 2 (Stx2) A(1) subunit. The binding of 11E10 to Stx2 neutralizes both the cytotoxic and lethal activities of Stx2, but the MAb does not bind to or neutralize Stx1 despite the 61% identity and 75% similarity in the amino acids of the A(1)...

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Detalhes bibliográficos
Main Authors: Smith, Michael J., Melton-Celsa, Angela R., Sinclair, James F., Carvalho, Humberto M., Robinson, Cory M., O'Brien, Alison D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708549/
https://ncbi.nlm.nih.gov/pubmed/19433543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00005-09
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