Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability

Helicobacter pylori VacA is a secreted pore-forming toxin that induces cell vacuolation in vitro and contributes to the pathogenesis of gastric cancer and peptic ulcer disease. We observed that purified VacA has relatively little effect on the viability of AGS gastric epithelial cells, but the prese...

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Udgivet i:Infect Immun
Main Authors: Foegeding, Nora J., Raghunathan, Krishnan, Campbell, Anne M., Kim, Sun Wook, Lau, Ken S., Kenworthy, Anne K., Cover, Timothy L., Ohi, Melanie D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434121/
https://ncbi.nlm.nih.gov/pubmed/30692181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00783-18
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