Virulence Traits of a Serogroup C Meningococcus and Isogenic cssA Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis

In serogroup C Neisseria meningitidis, the cssA (siaA) gene codes for an UDP-N-acetylglucosamine 2-epimerase that catalyzes the conversion of UDP-N-acetyl-α-d-glucosamine into N-acetyl-d-mannosamine and UDP in the first step in sialic acid biosynthesis. This enzyme is required for the biosynthesis o...

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Dades bibliogràfiques
Publicat a:Infect Immun
Autors principals: Colicchio, Roberta, Pagliuca, Chiara, Ricci, Susanna, Scaglione, Elena, Grandgirard, Denis, Masouris, Ilias, Farina, Fabrizio, Pagliarulo, Caterina, Mantova, Giuseppe, Paragliola, Laura, Leib, Stephen L., Koedel, Uwe, Pozzi, Gianni, Alifano, Pietro, Salvatore, Paola
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Bacterial Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434112/
https://ncbi.nlm.nih.gov/pubmed/30718288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00688-18
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