Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In Vitro Study of Mechanisms Associated with rpoB H553Y Mutation

Rifampin chemoprophylaxis against Neisseria meningitidis infections led to the onset of rifampin resistance in clinical isolates harboring point mutations in the rpoB gene, coding for the RNA polymerase β chain. These resistant strains are rare in medical practice, suggesting their decreased fitness...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Colicchio, Roberta, Pagliuca, Chiara, Pastore, Gabiria, Cicatiello, Annunziata Gaetana, Pagliarulo, Caterina, Talà, Adelfia, Scaglione, Elena, Sammartino, Josè Camilla, Bucci, Cecilia, Alifano, Pietro, Salvatore, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649176/
https://ncbi.nlm.nih.gov/pubmed/26416867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01746-15
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