Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In Vitro Study of Mechanisms Associated with rpoB H553Y Mutation

Rifampin chemoprophylaxis against Neisseria meningitidis infections led to the onset of rifampin resistance in clinical isolates harboring point mutations in the rpoB gene, coding for the RNA polymerase β chain. These resistant strains are rare in medical practice, suggesting their decreased fitness...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Colicchio, Roberta, Pagliuca, Chiara, Pastore, Gabiria, Cicatiello, Annunziata Gaetana, Pagliarulo, Caterina, Talà, Adelfia, Scaglione, Elena, Sammartino, Josè Camilla, Bucci, Cecilia, Alifano, Pietro, Salvatore, Paola
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649176/
https://ncbi.nlm.nih.gov/pubmed/26416867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01746-15
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