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ZEB1 protects skeletal muscle from damage and is required for its regeneration

The mechanisms linking muscle injury and regeneration are not fully understood. Here we report an unexpected role for ZEB1 regulating inflammatory and repair responses in dystrophic and acutely injured muscles. ZEB1 is upregulated in the undamaged and regenerating myofibers of injured muscles. Compa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Siles, Laura, Ninfali, Chiara, Cortés, Marlies, Darling, Douglas S., Postigo, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434033/
https://ncbi.nlm.nih.gov/pubmed/30910999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08983-8
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