Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck

Background: The majority of human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) present upregulation of the epidermal growth factor receptor (EGFR) and frequent alterations in the cyclin D1-cyclin dependent kinase (CDK) 4/6 (CDK 4/6)-retinoblastoma protein (pRb)...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Seront, Emmanuel, Schmitz, Sandra, Papier, Matthias, van Maanen, Aline, Henry, Stéphanie, Lonchay, Christophe, Rottey, Sylvie, van Caloen, Gabrielle, Machiels, Jean-Pascal
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433958/
https://ncbi.nlm.nih.gov/pubmed/30941307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00155
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