Empagliflozin Contributes to Polyuria via Regulation of Sodium Transporters and Water Channels in Diabetic Rat Kidneys

Besides lowering glucose, empagliflozin, a selective sodium-glucose cotransporter-2 (SGLT2) inhibitor, have been known to provide cardiovascular and renal protection due to effects on diuresis and natriuresis. However, the natriuretic effect of SGLT2 inhibitors has been reported to be transient, and...

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Pubblicato in:Front Physiol
Autori principali: Chung, Sungjin, Kim, Soojeong, Son, Mina, Kim, Minyoung, Koh, Eun Sil, Shin, Seok Joon, Ko, Seung-Hyun, Kim, Ho-Shik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433843/
https://ncbi.nlm.nih.gov/pubmed/30941057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00271
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