Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macr...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Ban, Yi, Dong, Wenjuan, Zhang, Lixing, Zhou, Tian, Altiti, Ahmad S., Ali, Khaleel, Mootoo, David R., Blaho, Victoria A., Hla, Timothy, Ren, Yi, Ma, Xiaojing
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433838/
https://ncbi.nlm.nih.gov/pubmed/30941120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00404
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