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Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine-and cotinine-enhanced alcoholic fatty liver in mice
CYP2A5 is a major enzyme responsible for nicotine and cotinine metabolism in mice. Nicotine and cotinine enhance alcoholic fatty liver in wild type (WT) mice but not in CYP2A5 knockout (KO) mice, and reactive oxygen species (ROS) generated during the CYP2A5-mediated metabolism contributes to the enh...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433518/ https://ncbi.nlm.nih.gov/pubmed/30876690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.03.021 |
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