Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade

Tumour cell immune evasion is a principal hallmark of successful metastasis. Tumour cells in the vasculature adopt a platelet cloak that efficiently suppresses the innate immune system by directly inhibiting Natural Killer (NK) cells, which normally function to neutralise spreading cancers. Here we...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cluxton, Christopher D., Spillane, Cathy, O'Toole, Sharon A., Sheils, Orla, Gardiner, Clair M., O'Leary, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433214/
https://ncbi.nlm.nih.gov/pubmed/30908480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211538
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