Combinatorial interactions of genetic variants in human cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of morbidity and mortality worldwide; yet how genetic variation and environmental factors impact DCM heritability remains unclear. Here, we report that compound genetic interactions between DNA sequence variants contribute to the complex heritability o...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Principais autores: Deacon, Dekker C., Happe, Cassandra L., Chen, Chao, Tedeschi, Neil, Manso, Ana Maria, Li, Ting, Dalton, Nancy D., Peng, Qian, Farah, Elie N., Gu, Yusu, Tenerelli, Kevin P., Tran, Vivien D., Chen, Ju, Peterson, Kirk L., Schork, Nicholas J., Adler, Eric D., Engler, Adam J., Ross, Robert S., Chi, Neil C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433174/
https://ncbi.nlm.nih.gov/pubmed/30923642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0348-9
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