Structural insights into the tyrosine phosphorylation–mediated inhibition of SH3 domain–ligand interactions

Src homology 3 (SH3) domains bind proline-rich linear motifs in eukaryotes. By mediating inter- and intramolecular interactions, they regulate the functions of many proteins involved in a wide variety of signal transduction pathways. Phosphorylation at different tyrosine residues in SH3 domains has...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Merő, Balázs, Radnai, László, Gógl, Gergő, Tőke, Orsolya, Leveles, Ibolya, Koprivanacz, Kitti, Szeder, Bálint, Dülk, Metta, Kudlik, Gyöngyi, Vas, Virág, Cserkaszky, Anna, Sipeki, Szabolcs, Nyitray, László, Vértessy, Beáta G., Buday, László
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433060/
https://ncbi.nlm.nih.gov/pubmed/30659095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004732
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