Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells

Upon inflammation, natural killer (NK) cells undergo metabolic changes to support their high energy demand for effector function and proliferation. The metabolic changes are usually accompanied by an increase in the expression of nutrient transporters, leading to increased nutrient uptake. Among var...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Almutairi, Saeedah Musaed, Ali, Alaa Kassim, He, William, Yang, Doo-Seok, Ghorbani, Peyman, Wang, Lisheng, Fullerton, Morgan D., Lee, Seung-Hwan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433059/
https://ncbi.nlm.nih.gov/pubmed/30696773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005892
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