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In vivo genome editing of ANGPTL3:a potential therapeutic strategy for coronary atherosclerosis?
Hyperlipidemia is an important risk factor for coronary heart disease. Chadwick and colleagues report significantly reduced blood lipid levels following CRISPR-based in vivo genome editing in mice to introduce loss-of-function mutations in ANGPTL3, a lipoprotein lipase inhibitor. The treatments were...
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| Publicado no: | Nat Rev Cardiol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6432938/ https://ncbi.nlm.nih.gov/pubmed/29618844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrcardio.2018.38 |
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