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Differential requirements for L-citrulline and L-arginine during anti-mycobacterial macrophage activity
Microbicidal nitric oxide (NO) production is reliant on inducible NO synthase (iNOS)- mediated L-arginine metabolism in macrophages (MΦs). L-arginine supply, however, can be restricted by arginase activity, resulting in inefficient NO and inhibition of anti-microbial MΦ function. MΦs circumvent this...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6432794/ https://ncbi.nlm.nih.gov/pubmed/26311904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500800 |
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