Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum

BACKGROUND: l-Histidine biosynthesis is embedded in an intertwined metabolic network which renders microbial overproduction of this amino acid challenging. This is reflected in the few available examples of histidine producers in literature. Since knowledge about the metabolic interplay is limited,...

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Veröffentlicht in:Biotechnol Biofuels
Hauptverfasser: Schwentner, Andreas, Feith, André, Münch, Eugenia, Stiefelmaier, Judith, Lauer, Ira, Favilli, Lorenzo, Massner, Christoph, Öhrlein, Johannes, Grund, Bastian, Hüser, Andrea, Takors, Ralf, Blombach, Bastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6432763/
https://ncbi.nlm.nih.gov/pubmed/30962820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-019-1410-2
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