Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition

BACKGROUND: Neutrophil elastase (NE) has been linked to lung neutrophil dysfunction in bronchiectasis and cystic fibrosis (CF), making NE inhibition a potential therapeutic target. NE inhibitor trials have given mixed result perhaps because not all patients have elevated airway NE activity. METHODS:...

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Detalhes bibliográficos
Publicado no:ERJ Open Res
Main Authors: Keir, Holly R., Fong, Christopher J., Crichton, Megan L., Barth, Philip, Chevalier, Eric, Brady, Gill, Kennedy, Gwen, Zimmermann, Johann, Bruijnzeel, Piet L.B., Dicker, Alison J., Chalmers, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: European Respiratory Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431753/
https://ncbi.nlm.nih.gov/pubmed/30918898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/23120541.00252-2018
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