Prostaglanin-E2 Potentiates the Suppressive Functions of Human Mononuclear Myeloid-Derived Suppressor Cells and Increases Their Capacity to Expand IL-10-Producing Regulatory T Cell Subsets

Myeloid-derived suppressor cells (MDSC) emerged as major factors driving the tumor progression due to numerous immunosuppressive mechanisms they possess. Prostaglandin (PG)E2 is shown critical for the induction of MDSC and their suppressive functions in vivo, but it is poorly understood how it affec...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tomić, Sergej, Joksimović, Bojan, Bekić, Marina, Vasiljević, Miloš, Milanović, Marijana, Čolić, Miodrag, Vučević, Dragana
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431635/
https://ncbi.nlm.nih.gov/pubmed/30936876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00475
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