COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis

Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and may present a therapeutic opportunity. Using serial single-cell RNA sequencing in an orthotopic mouse prostate cancer model, we find up-regulation of prolactin receptor as cancer cells that have disse...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Zheng, Yu, Comaills, Valentine, Burr, Risa, Boulay, Gaylor, Miyamoto, David T., Wittner, Ben S., Emmons, Erin, Sil, Srinjoy, Koulopoulos, Michael W., Broderick, Katherine T., Tai, Eric, Rengarajan, Shruthi, Kulkarni, Anupriya S., Shioda, Toshi, Wu, Chin-Lee, Ramaswamy, Sridhar, Ting, David T., Toner, Mehmet, Rivera, Miguel N., Maheswaran, Shyamala, Haber, Daniel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431196/
https://ncbi.nlm.nih.gov/pubmed/30819896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819303116
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