Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype

BACKGROUND: The efficacy of cell transplantation in heart failure is reportedly modest, but adjuvant drugs combined with cell therapy may improve this efficacy. Peroxisome proliferator-activated receptor (PPAR)γ, one of the hypoglycemic medicine for diabetes mellitus, reportedly enhances cytokine pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cardiovasc Diabetol
Hauptverfasser: Mori, Daisuke, Miyagawa, Shigeru, Matsuura, Ryohei, Sougawa, Nagako, Fukushima, Satsuki, Ueno, Takayoshi, Toda, Koichi, Kuratani, Toru, Tomita, Koichi, Maeda, Norikazu, Shimomura, Iichiro, Sawa, Yoshiki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431071/
https://ncbi.nlm.nih.gov/pubmed/30902059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-019-0829-x
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