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Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases
Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replication origins. We show here that the mechanism underlying this process involves a direct role for Myc in activation of Cdc45-MCM-GINS (CMG) helicases at Myc-targeted sites. Myc induces decondensation of hig...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430796/ https://ncbi.nlm.nih.gov/pubmed/30911685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0353-2 |
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