Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells

Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus. Cholesterol efflux to (apo)lipoproteins, via ATP-binding cassette (ABC) transporter A1 (ABCA1), can prevent intracellula...

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Sparad:
Bibliografiska uppgifter
I publikationen:Biosci Rep
Huvudupphovsmän: Caridis, Anna-Maria, Lightbody, Richard J., Tarlton, Jamie M.R., Dolan, Sharron, Graham, Annette
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430727/
https://ncbi.nlm.nih.gov/pubmed/30819824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181155
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