ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology

INTRODUCTION: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase neurodegeneration in a mouse model of frontotemporal dementia (FTD),...

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發表在:Alzheimers Dement (Amst)
Main Authors: Koriath, Carolin, Lashley, Tammaryn, Taylor, William, Druyeh, Ronald, Dimitriadis, Athanasios, Denning, Nicola, Williams, Julie, Warren, Jason D., Fox, Nick C., Schott, Jonathan M., Rowe, James B., Collinge, John, Rohrer, Jonathan D., Mead, Simon
格式: Artigo
語言:Inglês
出版: Elsevier 2019
主題:
Genetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430720/
https://ncbi.nlm.nih.gov/pubmed/30949567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2019.01.010
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