The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association

HIV-1 enters cells through binding between viral envelope glycoprotein (Env) and cellular receptors to initiate virus and cell fusion. HIV-1 Env precursor (gp160) is cleaved into two units noncovalently bound to form a trimer on virions, including a surface unit (gp120) and a transmembrane unit (gp4...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lu, Wuxun, Chen, Shuliang, Yu, Jingyou, Behrens, Ryan, Wiggins, Joshua, Sherer, Nathan, Liu, Shan-Lu, Xiong, Yong, Xiang, Shi-Hua, Wu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430531/
https://ncbi.nlm.nih.gov/pubmed/30651369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02128-18
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