Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt

The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream signaling influences cell proliferation, cell growth, and apoptosis, rendering Akt a prominent drug target. The unique activation mechanism of Akt involves a change of the relati...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Uhlenbrock, Niklas, Smith, Steven, Weisner, Jörn, Landel, Ina, Lindemann, Marius, Le, Thien Anh, Hardick, Julia, Gontla, Rajesh, Scheinpflug, Rebekka, Czodrowski, Paul, Janning, Petra, Depta, Laura, Quambusch, Lena, Müller, Matthias P., Engels, Bernd, Rauh, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430017/
https://ncbi.nlm.nih.gov/pubmed/30996949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05212c
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