Studying the phosphoryl transfer mechanism of the E. coli phosphofructokinase-2: from X-ray structure to quantum mechanics/molecular mechanics simulations

Phosphofructokinases (Pfks) catalyze the ATP-dependent phosphorylation of fructose-6-phosphate (F6P) and they are regulated in a wide variety of organisms. Although numerous aspects of the kinetics and regulation have been characterized for Pfks, the knowledge about the mechanism of the phosphoryl t...

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Sparad:
Bibliografiska uppgifter
I publikationen:Chem Sci
Huvudupphovsmän: Murillo-López, Juliana, Zinovjev, Kirill, Pereira, Humberto, Caniuguir, Andres, Garratt, Richard, Babul, Jorge, Recabarren, Rodrigo, Alzate-Morales, Jans, Caballero, Julio, Tuñón, Iñaki, Cabrera, Ricardo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Royal Society of Chemistry 2019
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429617/
https://ncbi.nlm.nih.gov/pubmed/30996866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00094a
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