Synthesis and Evaluation of pH-Sensitive Multifunctional Lipids for Efficient Delivery of CRISPR/Cas9 in Gene Editing

[Image: see text] CRISPR/Cas9 system is a promising approach for gene editing in gene therapy. Effective gene editing requires safe and efficient delivery of CRISPR/Cas9 system in target cells. Several new multifunctional pH-sensitive amino lipids were designed and synthesized with modification of t...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Sun, Da, Sun, Zhanhu, Jiang, Hongfa, Vaidya, Amita M., Xin, Rui, Ayat, Nadia R., Schilb, Andrew L., Qiao, Peter L., Han, Zheng, Naderi, Amirreza, Lu, Zheng-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429435/
https://ncbi.nlm.nih.gov/pubmed/30582790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00856
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