CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies

[Image: see text] Synaptic dysfunction is a pathological feature in many neurodegenerative disorders, including Alzheimer’s disease, and synaptic loss correlates closely with cognitive decline. Histone deacetylases (HDACs) are involved in chromatin remodeling and gene expression and have been shown...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Fuller, Nathan O., Pirone, Antonella, Lynch, Berkley A., Hewitt, Michael C., Quinton, Maria S., McKee, Timothy D., Ivarsson, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429430/
https://ncbi.nlm.nih.gov/pubmed/30496686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00620
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