Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia/thrombosis (HIT) is a serious immune reaction to heparins, characterized by thrombocytopenia and often severe thrombosis with high morbidity and mortality. HIT is mediated by IgG antibodies against heparin/platelet factor 4 antigenic complexes. These complexes are th...

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Опубликовано в: :Nat Commun
Главные авторы: Perdomo, José, Leung, Halina H. L., Ahmadi, Zohra, Yan, Feng, Chong, James J. H., Passam, Freda H., Chong, Beng H.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428879/
https://ncbi.nlm.nih.gov/pubmed/30899022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09160-7
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