Programmable Base Editing of the Sheep Genome Revealed No Genome-Wide Off-Target Mutations

Since its emergence, CRISPR/Cas9-mediated base editors (BEs) with cytosine deaminase activity have been used to precisely and efficiently introduce single-base mutations in genomes, including those of human cells, mice, and crop species. Most production traits in livestock are induced by point mutat...

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Udgivet i:Front Genet
Main Authors: Zhou, Shiwei, Cai, Bei, He, Chong, Wang, Ying, Ding, Qiang, Liu, Jiao, Liu, Yao, Ding, Yige, Zhao, Xiaoe, Li, Guanwei, Li, Chao, Yu, Honghao, Kou, Qifang, Niu, Wenzhi, Petersen, Bjoern, Sonstegard, Tad, Ma, Baohua, Chen, Yulin, Wang, Xiaolong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428697/
https://ncbi.nlm.nih.gov/pubmed/30930940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00215
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