Trace phosphate improves ZIC-pHILIC peak shape, sensitivity, and coverage for untargeted metabolomics

Existing hydrophilic interaction liquid chromatography (HILIC) methods, considered individually, each exhibit poor chromatographic performance for a substantial fraction of polar metabolites. In addition to limiting metabolome coverage, such deficiencies also complicate automated data processing. He...

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Udgivet i:J Proteome Res
Main Authors: Spalding, Jonathan L., Naser, Fuad J., Mahieu, Nathaniel G., Johnson, Stephen L., Patti, Gary J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6427830/
https://ncbi.nlm.nih.gov/pubmed/30160483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.8b00487
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