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Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis
The PBX1 homeodomain transcription factor is converted by t(1;19) chromosomal translocations in acute leukemia into the chimeric E2A-PBX1 oncoprotein. Fusion with E2A confers potent transcriptional activation and constitutive nuclear localization, bypassing the need for dimerization with protein par...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426973/ https://ncbi.nlm.nih.gov/pubmed/30894657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41393-w |
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