Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes

Psoriasis is a chronic skin disease characterized by hyperproliferation and impaired differentiation of epidermal keratinocytes accompanied by increased inflammation, suggesting that molecules with antiproliferation and anti-inflammatory abilities may be effective for its treatment. One of the key s...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Sun, Shuna, Zhang, Xiaojie, Xu, Mengru, Zhang, Fang, Tian, Fei, Cui, Jianfeng, Xia, Yangyang, Liang, Chenxi, Zhou, Shujie, Wei, Haifeng, Zhao, Hui, Wu, Guojing, Xu, Bohan, Liu, Xiaochen, Yang, Guanqun, Wang, Qinzhou, Zhang, Lei, Gong, Yaoqin, Shao, Changshun, Zou, Yongxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426889/
https://ncbi.nlm.nih.gov/pubmed/30894513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1510-8
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