Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52,...

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Vydáno v:Nat Commun
Hlavní autoři: Shooshtarizadeh, Peiman, Helness, Anne, Vadnais, Charles, Brouwer, Nelleke, Beauchemin, Hugues, Chen, Riyan, Bagci, Halil, Staal, Frank J. T., Coté, Jean-François, Möröy, Tarik
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426870/
https://ncbi.nlm.nih.gov/pubmed/30894540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09273-z
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