Cernunnos/Xlf Deficiency Results in Suboptimal V(D)J Recombination and Impaired Lymphoid Development in Mice

Xlf/Cernunnos is unique among the core factors of the non-homologous end joining (NHEJ) DNA double strand breaks (DSBs) repair pathway, in the sense that it is not essential for V(D)J recombination in vivo and in vitro. Unlike other NHEJ deficient mice showing a SCID phenotype, Xlf (−/−) mice presen...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Roch, Benoit, Abramowski, Vincent, Chaumeil, Julie, de Villartay, Jean-Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426757/
https://ncbi.nlm.nih.gov/pubmed/30923523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00443
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