Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study

OBJECTIVE: To investigate immunostimulatory effects of acetylsalicylic acid during experimental human endotoxemia and in sepsis patients. DESIGN: Double-blind, randomized, placebo-controlled study in healthy volunteers and ex vivo stimulation experiments using monocytes of septic patients. SETTING:...

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Bibliographic Details
Published in:Crit Care Med
Main Authors: Leijte, Guus P., Kiers, Dorien, van der Heijden, Wouter, Jansen, Aron, Gerretsen, Jelle, Boerrigter, Verin, Netea, Mihai G., Kox, Matthijs, Pickkers, Peter
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2019
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Feature Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426341/
https://ncbi.nlm.nih.gov/pubmed/30585832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003630
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