Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer. The bromodomain, present in several proteins, recognizes promotor lysine acetylation and recruits other transcription factors....

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Veröffentlicht in:Future Sci OA
Hauptverfasser: Alqahtani, Ali, Choucair, Khalil, Ashraf, Mushtaq, Hammouda, Danae M, Alloghbi, Abduraham, Khan, Talal, Senzer, Neil, Nemunaitis, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Science Ltd 2019
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426170/
https://ncbi.nlm.nih.gov/pubmed/30906568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fsoa-2018-0115
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