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Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy
Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer. The bromodomain, present in several proteins, recognizes promotor lysine acetylation and recruits other transcription factors....
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| 出版年: | Future Sci OA |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Future Science Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6426170/ https://ncbi.nlm.nih.gov/pubmed/30906568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fsoa-2018-0115 |
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