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Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated ca...

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Bibliografiske detaljer
Udgivet i:Eur Heart J
Main Authors: Stillitano, Francesca, Turnbull, Irene C., Karakikes, Ioannis, Nonnenmacher, Mathieu, Backeris, Peter, Hulot, Jean-Sébastien, Kranias, Evangelia G., Hajjar, Roger J., Costa, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: European Society of Cardiology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425468/
https://ncbi.nlm.nih.gov/pubmed/27450564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehw307
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