Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo

BACKGROUND: There is evidence that sirtuin 1 (SIRT1), a key regulator of nutrient metabolism, increases β-cell secretory function. Excess circulating fat, as seen in obesity, has been shown to decrease β-cell function, an effect that may involve decreased SIRT1 activity. Consequently, SIRT1 activati...

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Veröffentlicht in:Nutr Diabetes
Hauptverfasser: Desai, Tejas, Koulajian, Khajag, Ivovic, Aleksandar, Breen, Danna M., Luu, Lemieux, Tsiani, Evangelia L., Wheeler, Michael B., Giacca, Adria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424971/
https://ncbi.nlm.nih.gov/pubmed/30890694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41387-019-0075-z
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