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Structural mechanisms of phospholipid activation of the human TPC2 channel
Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2))-activated, Na(+) selective channel, in the ligand-bound and apo states. The apo structure capt...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6424560/ https://ncbi.nlm.nih.gov/pubmed/30860481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45222 |
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