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Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel
Organellar two-pore channels (TPCs) function as a homodimer with each subunit containing two homologous Shaker-like 6-TM repeats(1). They belong to the voltage-gated ion channel superfamily(2) and are ubiquitously expressed in animals and plants(3,4). Mammalian TPC1 and TPC2 are localized to the end...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886804/ https://ncbi.nlm.nih.gov/pubmed/29562233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature26139 |
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