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Clinical Epigenetic Therapies Disrupt Sex Chromosome Dosage Compensation in Human Female Cells
Sex chromosome gene dosage compensation is required to ensure equivalent levels of X-linked gene expression between males (46, XY) and females (46, XX). To achieve similar expression, X-chromosome inactivation (XCI) is initiated in female cells during early stages of embryogenesis. Within each cell,...
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| Publicado no: | Gend Genome |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6424500/ https://ncbi.nlm.nih.gov/pubmed/30899898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2470289718787106 |
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