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A stochastic simulation of skeletal muscle calcium transients in a structurally realistic sarcomere model using MCell

Skeletal muscle contraction is initiated when an action potential triggers the release of Ca(2+) into the sarcomere in a process referred to as excitation-contraction coupling. The speed and scale of this process makes direct observation very challenging and invasive. To determine how the concentrat...

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Publicat a:PLoS Comput Biol
Autors principals: Holash, Robert John, MacIntosh, Brian R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424466/
https://ncbi.nlm.nih.gov/pubmed/30845143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006712
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