Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats

Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell deat...

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Vydáno v:Front Neurosci
Hlavní autoři: Dobryakova, Yulia V., Volobueva, Maria N., Manolova, Anna O., Medvedeva, Tatiana M., Kvichansky, Alexey A., Gulyaeva, Natalia V., Markevich, Vlamidir A., Stepanichev, Mikhail Yu., Bolshakov, Alexey P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424051/
https://ncbi.nlm.nih.gov/pubmed/30930730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00146
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