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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
[Image: see text] Bifunctional degrader molecules, known as proteolysis-targeting chimeras (PROTACs), function by recruiting a target to an E3 ligase, forming a target/PROTAC/ligase ternary complex. Despite the importance of this key intermediate species, no detailed validation of a method to direct...
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| 出版年: | ACS Chem Biol |
|---|---|
| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2019
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6423499/ https://ncbi.nlm.nih.gov/pubmed/30721025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00092 |
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