Doxorubicin exposure causes subacute cardiac atrophy dependent upon the striated muscle-specific ubiquitin ligase Muscle Ring Finger-1

BACKGROUND: Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of numerous malignancies. The primary dose-limiting adverse effect of anthracyclines is cardiotoxicity that often presents as heart failure due to dilated cardiomyopathy years after anthracycline expos...

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Veröffentlicht in:Circ Heart Fail
Hauptverfasser: Willis, Monte S., Parry, Traci L., Brown, David I., Mota, Roberto I., Huang, Wei, Beak, Ju Youn, Sola, Michael, Zhou, Cynthia, Hicks, Sean T, Caughey, Melissa C., D’agostino, Ralph B., Jordan, Jennifer, Hundley, W. Gregory, Jensen, Brian C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422170/
https://ncbi.nlm.nih.gov/pubmed/30871347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005234
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