Doxorubicin exposure causes subacute cardiac atrophy dependent upon the striated muscle-specific ubiquitin ligase Muscle Ring Finger-1

BACKGROUND: Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of numerous malignancies. The primary dose-limiting adverse effect of anthracyclines is cardiotoxicity that often presents as heart failure due to dilated cardiomyopathy years after anthracycline expos...

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Detalhes bibliográficos
Publicado no:Circ Heart Fail
Main Authors: Willis, Monte S., Parry, Traci L., Brown, David I., Mota, Roberto I., Huang, Wei, Beak, Ju Youn, Sola, Michael, Zhou, Cynthia, Hicks, Sean T, Caughey, Melissa C., D’agostino, Ralph B., Jordan, Jennifer, Hundley, W. Gregory, Jensen, Brian C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422170/
https://ncbi.nlm.nih.gov/pubmed/30871347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005234
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