Quantitative live-cell imaging and 3D modeling reveal critical functional features in the cytosolic complex of phagocyte NADPH oxidase

Phagocyte NADPH oxidase produces superoxide anions, a precursor of reactive oxygen species (ROS) critical for host responses to microbial infections. However, uncontrolled ROS production contributes to inflammation, making NADPH oxidase a major drug target. It consists of two membranous (Nox2 and p2...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ziegler, Cornelia S., Bouchab, Leïla, Tramier, Marc, Durand, Dominique, Fieschi, Franck, Dupré-Crochet, Sophie, Mérola, Fabienne, Nüße, Oliver, Erard, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422089/
https://ncbi.nlm.nih.gov/pubmed/30630949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006864
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