ZFP148 binds cooperatively with NF-1 to inhibit Smooth Muscle Marker Gene Expression during Abdominal Aortic Aneurysm Formation

OBJECTIVE: The goal of this study was to determine the role of ZFP148 in aneurysm formation. APPROACH AND RESULTS: ZFP148 mRNA expression increased at day 3, 7, 14, 21 and 28 following during AAA formation in C57BL/6 mice. Loss of ZFP148 conferred AAA protection using ERTCre+ ZFP148 flx/flx mice. In...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Salmon, Morgan, Schaheen, Basil, Spinosa, Michael, Montgomery, William, Pope, Nicolas H., Davis, John P., Johnston, William F., Sharma, Ashish K., Owens, Gary K., Merchant, Juanita L., Zehner, Zendra E., Upchurch, Gilbert R., Ailawadi, Gorav
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422047/
https://ncbi.nlm.nih.gov/pubmed/30580567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311136
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